Infectious Disease Dynamics

Using different data sources and
mathematical methods to understand
the complex dynamics of the HIV epidemic and beyond

Our team brings together expertise from mathematics, biology, medicine, and data science

The People Who Make It Happen

Current Team

The People Who Make It Happen

Current Team

The People Who Made It Happen

Past Members

The People Who Made It Happen

Past Members

Whats New

News & Stories

Insights from Our Research

Selected Publications

Inflammation and B cell activation define a plasma proteome signature predicting tuberculosis in people with HIV

Kusejko K, Arefian M, Duroux D, Zeeb M, Dollé C, Hoffmann M, Labhardt N, Wandeler G, Cavassini M, Haller S, Bernasconi E, Russenberger D, Kouyos RD, Günthard HF, Collins BC, Nemeth J; Swiss HIV Cohort Study

mBio. 2025 Aug 28

Link to publication

Phylogenetics and molecular evolution to understand and curb the HIV pandemic

Günthard HF, Kusejko K, Kouyos RD

Nature Reviews Microbiology. 2025 Jun 30

Link to publication

HIV-1 Low-Level Viremia Predicts Viral Failure in Participants on Antiretroviral Therapy in the Swiss HIV Cohort Study

Lanz C, Meier J, Stöckle M, Furrer H, Calmy A, Cavassini M, Bernasconi E, Schmid P, Braun DL, Kouyos RD, Loosli T, Kusejko K*, Günthard HF*; Swiss HIV Cohort Study

Clinical Infectious Diseases, 2025 Aug 1;81(1):57-66

Link to publication

Machine Learning-based Prediction of Active Tuberculosis in People With Human Immunodeficiency Virus Using Clinical Data

Lena Bartl, Marius Zeeb, Marisa Kälin, Tom Loosli, Julia Notter, Hansjakob Furrer, Matthias Hoffmann, Hans H Hirsch, Robert Zangerle, Katharina Grabmeier-Pfistershammer, Michael Knappik, Alexandra Calmy, Jose Damas Fernandez, Niklaus D Labhardt, Enos Bernasconi, Huldrych F Günthard, Roger D Kouyos, Katharina Kusejko*, Johannes Nemeth*, the Swiss HIV Cohort Study

Clinical Infectious Diseases, 2025, ciaf149

Link to publication

Mycobacteria beyond disease

Terence K. Tutumlu, Cédric Dollé, Katharina Kusejko, Sébastien Gagneux, Silvio D. Brugger, Huldrych F. Günthard, Johannes Nemeth

Trends in Microbiology, 2025, ISSN 0966-842X

Link to publication

Threshold sensitivity analysis for HIV-1 transmission cluster detection using different genomic regions and subtypes

Obeng BM, Kouyos RD, Kusejko K, Salazar-Vizcaya L, Günthard HF, Kelleher AD, Di Giallonardo F; Swiss HIV Cohort Study

Virology. 2025 Jul;608:110558.

Link to publication

Late Re-Engagement Into HIV Care Among Adults in the Swiss HIV Cohort Study

Haas AD, Kusejko K, Cavassini M, Günthard H, Stöckle M, Calmy A, Bernasconi E, Schmid P, Egger M, Wandeler G; Swiss HIV Cohort Study

J Acquir Immune Defic Syndr. 2025 Apr 15;98(5):491-500

Link to publication

Time Trends in Causes of Death in People With HIV: Insights From the Swiss HIV Cohort Study

S. R. Weber, J. J. Duran Ramirez, M. Hentzien, M. Cavassini, E. Bernasconi, E. Hofmann, H. Furrer, H. Kovari, M. Stöckle, P. Schmid, D. Haerry, D. L. Braun, H. F. Günthard*, K. Kusejko*, and the Swiss HIV Cohort Study

Clinical Infectious Diseases, July 2024

Link to publication

Infectious disease events in people with HIV receiving kidney transplantation: Analysis of the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study

Katharina Kusejko, Roger D Kouyos, Enos Bernasconi, Katia Boggian, Dominique L Braun, Alexandra Calmy, Matthias Cavassini  , Christian van Delden, Hansjakob Furrer, Christian Garzoni, Hans H Hirsch, Cedric Hirzel, Oriol Manuel, Patrick Schmid, Nina Khanna, Fadi Haidar, Marco Bonani, Dela Golshayan, Michael Dickenmann, Daniel Sidler, Aurelia Schnyder, Nicolas J Mueller, Huldrych F Günthard, Peter W Schreiber; Swiss HIV Cohorts Study and the Swiss Transplant Cohort Study

BMC Infectious Diseases, October 2024

Link to publication

Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?

Katharina Kusejko, Dionysios Neofytos, Christian van Delden, Hans H Hirsch, Pascal Meylan, Katia Boggian, Cedric Hirzel, Christian Garzoni, Daniel Sidler, Aurelia Schnyder, Stefan Schaub, Déla Golshayan, Fadi Haidar, Marco Bonani, Roger D Kouyos, Nicolas J Mueller, Peter W Schreiber; Swiss Transplant Cohort Study

Open Forum Infectious Diseases, February 2024

Link to publication

Migrating a Well-Established Longitudinal Cohort Database From Oracle SQL to Research Electronic Data Entry (REDCap): Data Management Research and Design Study

Kusejko K, Smith D, Scherrer A, Paioni P, Kohns Vasconcelos M, Aebi-Popp K, Kouyos R, Günthard H, Kahlert C, Swiss HIV Cohort Study and the Swiss Mother and Child HIV Cohort Study

JMIR Form Res 2023;7:e44567

Link to publication

Incidence of sexually transmitted infections and association with behavioural factors: Time-to-event analysis of a large pre-exposure prophylaxis (PrEP) cohort

Hovaguimian F, Kouyos RD, Kusejko K, Schmidt AJ, Tarr PE, Bernasconi E, Braun DL, Calmy A, Notter J, Stoeckle M, Surial B, Christinet V, Darling KEA, Depmeier C, Läuchli S, Reinacher M, Rasi M, Nicca D, Bruggmann P, Haerry D, Bize R, Low N, Vock F, El Amari EB, Böni J, Bosshard PP, Fehr JS, Hampel B; SwissPrEPared Cohort Study

HIV Medicine. 2024 Jan;25(1):117-128

Link to publication

Understanding the Decline of Incident, Active Tuberculosis in People With Human Immunodeficiency Virus in Switzerland

Zeeb M, Tepekule B, Kusejko K, Reiber C, Kälin M, Bartl L, Notter J, Furrer H, Hoffmann M, Hirsch HH, Calmy A, Cavassini M, Labhardt ND, Bernasconi E, Braun DL, Günthard HF, Kouyos RD, Nemeth J; Swiss HIV Cohort Study

Clinical Infectious Diseases. 2023 Nov 11;77(9):1303-1311

Link to publication

Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics

Kusejko K, Tschumi N, Chaudron SE, Nguyen H, Battegay M, Bernasconi E, Böni J, Huber M, Calmy A, Cavassini M, Egle A, Grabmeier-Pfistershammer K, Haas B, Hirsch H, Klimkait T, Öllinger A, Perreau M, Ramette A, Flury BB, Sarcletti M, Scherrer A, Schmid P, Yerly S, Zangerle R, Günthard HF, Kouyos RD; Swiss HIV Cohort Study and the Austrian HIV Cohort Study

J Acquir Immune Defic Syndr. 2022 Aug 1;90(4):e4-e12

Link to publication

Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group

Nguyen H, Hampel B, Garcia Nuñez D, Battegay M, Hachfeld A, Bernasconi E, Calmy A, Cavassini M, Vernazza P, Fellay J, Rudolph H, Huber M, Leuzinger K, Perreau M, Scherrer A, Ramette AN, Yerly S, Günthard HF, Kouyos RD*, Kusejko K*; Swiss HIV Cohort Study

Clin Infect Dis. 2022 Apr 28;74(8):1468-1475

Link to publication

Sustained Effect on Hepatitis C Elimination Among Men Who Have Sex With Men in the Swiss HIV Cohort Study: A Systematic Re-Screening for Hepatitis C RNA Two Years Following a Nation-Wide Elimination Program

Katharina Kusejko, Luisa Salazar-Vizcaya, Cyril Shah, Marcel Stöckle, Charles Béguelin, Patrick Schmid, Marie Ongaro, Katherine Darling, Enos Bernasconi, Andri Rauch, Roger D Kouyos, Huldrych F Günthard, Jürg Böni, Jan S Fehr, Dominique L Braun, Swiss HIV Cohort Study

Clinical Infectious Diseases, Volume 75, Issue 10, 15 November 2022, Pages 1723–1731

Link to publication

The Interplay Between Replication Capacity of HIV-1 and Surrogate Markers of Disease

Rindler AE*, Kusejko K*, Kuster H, Neumann K, Leemann C, Zeeb M, Chaudron SE, Braun DL, Kouyos RD, Metzner KJ, Günthard HF

J Infect Dis. 2022 Sep 21;226(6):1057-1068

Link to publication

Developing and testing a Corona VaccinE tRiAL pLatform (COVERALL) to study Covid-19 vaccine response in immunocompromised patients

Kusejko K, Chammartin F, Smith D, Odermatt M, Schuhmacher J, Koller M, Günthard HF, Briel M, Bucher HC, Speich B; Swiss HIV Cohort Study; Swiss Transplant Cohort Study

BMC Infectious Diseases. 2022 Jul 28;22(1):654

Link to publication

Determinants of antibody response to severe acute respiratory syndrome coronavirus 2 mRNA vaccines in people with HIV

Chammartin F, Kusejko K, Pasin C, Trkola A, Briel M, Amico P, Stoekle MP, Eichenberger AL, Hasse B, Braun DL, Schuurmans MM, Müller TF, Tamm M, Mueller NJ, Rauch A, Koller MT, Günthard HF, Bucher HC, Speich B, Abela IA; and the Swiss HIV Cohort Study

AIDS. 2022 Aug 1;36(10):1465-1468

Link to publication

Collaborative Challenges of Multi-Cohort Projects in Pharmacogenetics-Why Time Is Essential for Meaningful Collaborations

Franchini F, Kusejko K, Marzolini C, Tellenbach C, Rossi S, Stampf S, Koller M, Stoyanov J, Möller B, Leichtle AB

JMIR Form Res. 2022 Sep 29;6(9):e36759

Link to publication

The Impact of Surgical Strategy and Rifampin on Treatment Outcome in Cutibacterium Periprosthetic Joint Infections

Katharina Kusejko, Álvaro Auñón, Bernhard Jost, Benito Natividad, Carol Strahm, Christine Thurnheer, Daniel Pablo-Marcos, Dorsaf Slama, Giulia Scanferla, Ilker Uckay, Isabelle Waldmann, Jaime Esteban, Jaime Lora-Tamayo, Martin Clauss, Marta Fernandez-Sampedro, Marjan Wouthuyzen-Bakker, Matteo Carlo Ferrari, Natalie Gassmann, Parham Sendi, Philipp Jent, Philippe C Morand, Prakhar Vijayvargiya, Rihard Trebše, Robin Patel, Roger D Kouyos, Stéphane Corvec, Tobias Siegfried Kramer, Vincent A Stadelmann, Yvonne Achermann, on behalf of the ESCMID Study Group for Implant-Associated Infections (ESGIAI)

Clinical Infectious Diseases, Volume 72, Issue 12, 15 June 2021, Pages e1064–e1073

Link to publication 

Using longitudinally sampled viral nucleotide sequences to characterize the drivers of HIV-1 transmission

Reichmuth ML, Chaudron SE, Bachmann N, Nguyen H, Böni J, Metzner KJ, Perreau M, Klimkait T, Yerly S, Hirsch HH, Hauser C, Ramette A, Vernazza P, Cavassini M, Bernasconi E, Günthard HF, Kusejko K*, Kouyos RD*; Swiss HIV Cohort Study

HIV Med. 2021 May;22(5):346-359

Link to publication 

Impact of an electronic alert on prescription patterns of meropenem, voriconazole and caspofungin

Chok L*, Kusejko K*, Eberhard N, Chaudron SE, Saleschus D, Kocher C, Kouyos RD, Weber R, Kuster SP

BMC Infectious Diseases 2021 Dec 20;21(1):1263

Link to publication 

A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®

Speich B, Chammartin F, Smith D, Stoeckle MP, Amico P, Eichenberger AL, Hasse B, Schuurmans MM, Müller T, Tamm M, Dickenmann M, Abela IA, Trkola A, Hirsch HH, Manuel O, Cavassini M, Hemkens LG, Briel M, Mueller NJ, Rauch A, Günthard HF, Koller MT, Bucher HC, Kusejko K; study groups from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study

Trials. 2021 Oct 21;22(1):724

Link to publication 

Differences Between Infectious Disease Events in First Liver Transplant Versus Retransplantation in the Swiss Transplant Cohort Study

Kusejko K, Neofytos D, Hirsch HH, Meylan P, Boggian K, Hirzel C, Garzoni C, Kouyos RD, Mueller NJ, Schreiber PW; Swiss Transplant Cohort Study. Differences Between Infectious Disease Events in First Liver Transplant Versus Retransplantation in the Swiss Transplant Cohort Study

Liver Transplantation 2021 Sep;27(9):1283-1290

Link to publication 

Diagnosis of latent tuberculosis infection is associated with reduced HIV viral load and lower risk for opportunistic infections in people living with HIV

Kusejko K, Günthard HF, Olson GS, Zens K, Darling K, Khanna N, Furrer H, Vetter P, Bernasconi E, Vernazza P, Hoffmann M, Kouyos RD, Nemeth J; Swiss HIV Cohort Study. 

PLoS Biology, 2020 Dec 7;18(12):e300096

Link to publication 

Chemsex drugs on the rise: a longitudinal analysis of the Swiss HIV Cohort Study from 2007 to 2017

Hampel B*, Kusejko K*, Kouyos RD, Böni J, Flepp M, Stöckle M, Conen A, Béguelin C, Künzler-Heule P, Nicca D, Schmidt AJ, Nguyen H, Delaloye J, Rougemont M, Bernasconi E, Rauch A, Günthard HF, Braun DL, Fehr J; Swiss HIV Cohort Study group

HIV Med. 2020 Apr;21(4):228-239

Link to publication 

Differences in social and mental well-being of long-term survivors among people who inject drugs and other participants in the Swiss HIV Cohort Study: 1980-2018

Kusejko K, Marzel A, Nguyen H, Chaudron SE, Bachmann N, Weber R, Bruggmann P, Roth JA, Bernasconi E, Calmy A, Cavassini M, Bregenzer A, Böni J, Yerly S, Klimkait T, Perreau M, Walti LN, Günthard HF, Kouyos RD; Swiss HIV Cohort Study. 

Antiviral Therapy 2020;25(1):43-54

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Self-reported Neurocognitive Impairment in People Living With Human Immunodeficiency Virus (HIV): Characterizing Clusters of Patients With Similar Changes in Self-reported Neurocognitive Impairment, 2013-2017, in the Swiss HIV Cohort Study

Kusejko K, Salazar-Vizcaya L, Braun DL, Tarr PE, Bernasconi E, Doco-Lecompte T, Cavassini M, Schmid P, Du Pasquier R, Hauser C, Günthard HF, Kouyos RD. 

Clinical Infectious Diseases 2020 Jul 27;71(3):637-644

Link to publication 

A Systematic Phylogenetic Approach to Study the Interaction of HIV-1 With Coinfections, Noncommunicable Diseases, and Opportunistic Diseases

Kusejko K, Bachmann N, Chaudron SE, Nguyen H, Braun DL, Hampel B, Battegay M, Bernasconi E, Calmy A, Cavassini M, Hoffmann M, Böni J, Yerly S, Klimkait T, Perreau M, Rauch A, Günthard HF, Kouyos RD; Swiss HIV Cohort Study 

J Infect Dis. 2019 Jun 19;220(2):244-253

Link to publication 

Bridging the gap between HIV epidemiology and antiretroviral resistance evolution: Modelling the spread of resistance in South Africa

Hauser A, Kusejko K, Johnson LF, Wandeler G, Riou J, Goldstein F, Egger M, Kouyos RD

PLoS Comput Biol. 2019 Jun 24;15(6):e1007083

Link to publication 

Quantifying the drivers of HIV transmission and prevention in men who have sex with men: a population model-based analysis in Switzerland

Kusejko K, Marzel A, Hampel B, Bachmann N, Nguyen H, Fehr J, Braun DL, Battegay M, Bernasconi E, Calmy A, Cavassini M, Hoffmann M, Böni J, Yerly S, Klimkait T, Perreau M, Rauch A, Günthard HF, Kouyos RD; Swiss HIV Cohort Study

HIV Med. 2018 Nov;19(10):688-697

Link to publication 

Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study

Kusejko K, Kadelka C, Marzel A, Battegay M, Bernasconi E, Calmy A, Cavassini M, Hoffmann M, Böni J, Yerly S, Klimkait T, Perreau M, Rauch A, Günthard HF, Kouyos RD; Swiss HIV Cohort Study

Virus Evol. 2018 Sep 18;4(2):vey024

Link to publication 

Jobs

Open Positions

We are always open to enthusiastic and motivated students interested in conducting their Master’s thesis or MD thesis in our group. Please contact us if you are interested!

At the moment, there are no open PhD or PostDoc positions in our group.

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If you have any specific questions concerning the work of our group, feel free to contact us.